Premier League action is back in the spotlight this weekend, following another thrilling European midweek.Based on an enthralling start to the season, this could be one of the most exciting and eagerly-contested title races in the competitions recent history.With only one point separating the top six sides heading into the weekend, we take a look at the four most intriguing Premier League fixtures to look forward to this weekend.Manchester United to bounce back against EvertonSaturdays Premier League action kicks off at Old Trafford as Manchester United and Everton lock horns in a top-five six-pointer.Fresh from a nail-biting 2-1 Champions League win over Villarreal over the midweek, United will look to recover from last weekends 1-0 home lo s to Terrance Mitchell Jersey Aston Villa.Standing in their way will be a high-flying Everton side that have registered as many points (13) as their hosts in the Premier League this season.Despite Cristiano Ronaldos late heroics helping United edge past Villarreal on Wednesday, the Red Devils have not been at their best at Old Trafford this term.After winning their first two Premier League home fixtures by an aggregate scoreline of 9-2, Ole Gunner Solskjaers men lost their subsequent two domestic matches at Old Trafford by an identical 1-0 scoreline.However, United can find confidence in their outstanding overall Premier League H2H record at their host venue, having lost just two of their 29 meetings with Everton at Old Trafford (W20, D7, L2).Additionally, the Red Devils have netted an average of 2.5 goals per match acro s their last four top-flight H2Hs at home (W2, D2).So there is plenty of Ahkello Witherspoon Jersey reason for optimism in Solskjaers camp as United hope to whittle down a one-point gap on Liverpool at the summit.Prediction: Manchester United 2-1 EvertonNo margin for error at Stamford BridgeStamford Bridge is the venue as Chelsea take on Southampton in a must-win Premier League fixture.A brace of 1-0 defeats to Manchester City and Juventus in the Premier League and Champions League have seen Chelsea lose back-to-back competitive fixtures for only the second time under Thomas Tuchel.A narrow home lo s to Man City last time out means the London heavyweights could suffer consecutive league defeats at Stamford Bridge for the first time since December 2019.That prospect is not beyond the realm of po sibility, as they have failed to beat Southampton in three Premier League meetings in a row (D2, L1), last enduring a longer winle s streak against this opposition between October 1990 and December 1993.However, Southamptons showings this season justify their underdog status in this encounter, with the Saints taking the field as one of just five sides in the Premier League yet to taste succe s in 2021/22 (D4, L2).Embroiled Joe Montana Jersey in a keenly-contested multi-side scrap at the top of the standings, Chelsea can ill-afford a slip-up against the underperforming visitors.Since Tuchel arrived at the helm in January, the Blues have never failed to win three straight matches acro s all competitions, and that trend should continue here.Prediction: Chelsea 2-0 SouthamptonNuno Espirito Santo hopes to ease the heat against Aston VillaOut-of-sorts Tottenham Hotspur will be desperate to return to winning ways in the Premier League when they face Aston Villa at home on Sunday.Spurs flying start to the season under Nuno Espirito Santo has suffered a series of setbacks in the wake of Septembers international break.The Londoners have gone from three consecutive 1-0 league victories to a hat-trick of top-flight defeats, scoring just one goal while conceding nine in return in that run.It has been almost 17 years since lost four Premier League matches on the trot, last doing so in November 2004.However, Spurs lost their most recent league meeting with Villa at home, with the visitors quick-fire first-half double cancelling out Steven Bergwijns early opener.After claiming a 2-1 victory at the Tottenham Hotspur Stadium in mid-May, Villa are gunning for two succe sive away league wins over Tottenham for the first time since September 2008.But achieving that feat wont be a simple task.In the build-up to Spurs Europa Conference League meeting with Mura, amid a notable dip in form as he begins to feel the heat.Tottenham will fight tooth and nail to respond to last weekends dismal Dante Pettis Jersey 3-1 lo s to Arsenal and can eke out a narrow win.Prediction: Tottenham Hotspur 2-1 Aston VillaClash of titans at AnfieldSundays Premier League action concludes at Anfield, as Liverpool and Manchester City go head-to-head in a blockbuster Premier League fixture.With just one point separating the sides ahead of the kick-off, Pep Guardiolas side will be looking to take all three points and the Reds spot in the table.The Cityzens put Liverpool to the sword in their most recent Premier League Dontae Johnson Jersey meeting at Anfield, pulling off an overwhelming 4-1 triumph in early February.That victory brought Citys disastrous 17-game winle s top-flight streak at this famous venue (D5, L12), giving the Etihad outfit a chance to rack up back-to-back league wins at Anfield for the first time since 1953.However, Jurgen Klopps men are arguably the sternest test any Premier League side could face at the moment, as they head into proceedings as the only side yet to lose a league match this season (W4, D2).Liverpools form has taken a significant U-turn since their last home clash against City, as theyve gone from an underwhelming six-game losing streak in the Premier League at home to an intimidating 16-match unbeaten top-flight run (W12, D4).As the leagues most prolific attack (Liverpool, 15 goals) goes up against the divisions best defence (Man City, one goal), it is almost impo sible to make any predictions here.Prediction: Liverpool vs Manchester City: Kick back and enjoy the show.Read: .